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human hnscc cell lines scc15  (ATCC)


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    ATCC human hnscc cell lines scc15
    Human Hnscc Cell Lines Scc15, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 645 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/human+hnscc+cell+lines+scc15/SCC-15/pm41976369-72-4-15
    Average 96 stars, based on 645 article reviews
    human hnscc cell lines scc15 - by Bioz Stars, 2026-09
    96/100 stars

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    Cell Culture:

    Article Title: Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress-Associated Degradation of EZH2/MYC Axis.
    Article Snippet: .. Cell Culture and Clinical Samples: The human HNSCC cell lines SCC15 and SCC25, gastric cancer (GC) cell lines AGS and MNK45, colorectal cancer (CRC) cell lines SW480 and LOVO, and the human embryonic kidney cell line HEK293T cells were obtained from the American Type Culture Collection (ATCC, USA). .. All cell lines were maintained in F12/DMEM medium (Gibco, USA) supplementary with 10% fetal bovine serum (Gibco, USA), 10 mm HEPES, 1 mm sodium pyruvate, 100 units mL−1 penicillin, and 100 units mL−1 streptomycin (Gibco, USA).



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    human hnscc cell lines scc15  (ATCC)
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    Human Hnscc Cell Lines Scc15, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    human hnscc cell line scc15  (ATCC)
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    PTC209-induced DNA damage activates NF-κB signaling pathway in CSCs (A) Immunostaining and quantification of pH2A.X (red) in HNSCC cells treated with PTC209. DAPI stained the nuclei blue. Scale bar, 20 μm. (B) Percentage of pH2A.X in HNSCC cells from different treatment groups as indicated. Data are shown as the mean ± SD. ∗∗ p < 0.01 using an unpaired Student’s t test. (C) Western blot analysis of pH2A.X in HN6 and <t>SCC15</t> cells treated with PTC209. (D and E) Histogram of the top 10 most-enriched GO (D) and KEGG (E) terms for upregulated genes (FC > 2) in ALDH + HN6 cells treated with PTC209. The red rectangles indicate genes related to NF-κB signaling. (F) Western blot analysis of pIKK-α/β, IKK-α, IKK-β, pIκB-α, IκB-α, p-P65, and P65 in HNSCC cells with PTC209 treatment. (G) Representative images of p65 immunostaining (green) in HN6 and SCC15 cells treated with PTC209. DAPI stained the nuclei (blue). Scale bar, 20 μm. See also .
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    PTC209-induced DNA damage activates NF-κB signaling pathway in CSCs (A) Immunostaining and quantification of pH2A.X (red) in HNSCC cells treated with PTC209. DAPI stained the nuclei blue. Scale bar, 20 μm. (B) Percentage of pH2A.X in HNSCC cells from different treatment groups as indicated. Data are shown as the mean ± SD. ∗∗ p < 0.01 using an unpaired Student’s t test. (C) Western blot analysis of pH2A.X in HN6 and <t>SCC15</t> cells treated with PTC209. (D and E) Histogram of the top 10 most-enriched GO (D) and KEGG (E) terms for upregulated genes (FC > 2) in ALDH + HN6 cells treated with PTC209. The red rectangles indicate genes related to NF-κB signaling. (F) Western blot analysis of pIKK-α/β, IKK-α, IKK-β, pIκB-α, IκB-α, p-P65, and P65 in HNSCC cells with PTC209 treatment. (G) Representative images of p65 immunostaining (green) in HN6 and SCC15 cells treated with PTC209. DAPI stained the nuclei (blue). Scale bar, 20 μm. See also .
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    PTC209-induced DNA damage activates NF-κB signaling pathway in CSCs (A) Immunostaining and quantification of pH2A.X (red) in HNSCC cells treated with PTC209. DAPI stained the nuclei blue. Scale bar, 20 μm. (B) Percentage of pH2A.X in HNSCC cells from different treatment groups as indicated. Data are shown as the mean ± SD. ∗∗ p < 0.01 using an unpaired Student’s t test. (C) Western blot analysis of pH2A.X in HN6 and <t>SCC15</t> cells treated with PTC209. (D and E) Histogram of the top 10 most-enriched GO (D) and KEGG (E) terms for upregulated genes (FC > 2) in ALDH + HN6 cells treated with PTC209. The red rectangles indicate genes related to NF-κB signaling. (F) Western blot analysis of pIKK-α/β, IKK-α, IKK-β, pIκB-α, IκB-α, p-P65, and P65 in HNSCC cells with PTC209 treatment. (G) Representative images of p65 immunostaining (green) in HN6 and SCC15 cells treated with PTC209. DAPI stained the nuclei (blue). Scale bar, 20 μm. See also .
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    PTC209-induced DNA damage activates NF-κB signaling pathway in CSCs (A) Immunostaining and quantification of pH2A.X (red) in HNSCC cells treated with PTC209. DAPI stained the nuclei blue. Scale bar, 20 μm. (B) Percentage of pH2A.X in HNSCC cells from different treatment groups as indicated. Data are shown as the mean ± SD. ∗∗ p < 0.01 using an unpaired Student’s t test. (C) Western blot analysis of pH2A.X in HN6 and SCC15 cells treated with PTC209. (D and E) Histogram of the top 10 most-enriched GO (D) and KEGG (E) terms for upregulated genes (FC > 2) in ALDH + HN6 cells treated with PTC209. The red rectangles indicate genes related to NF-κB signaling. (F) Western blot analysis of pIKK-α/β, IKK-α, IKK-β, pIκB-α, IκB-α, p-P65, and P65 in HNSCC cells with PTC209 treatment. (G) Representative images of p65 immunostaining (green) in HN6 and SCC15 cells treated with PTC209. DAPI stained the nuclei (blue). Scale bar, 20 μm. See also .

    Journal: Cell Reports Medicine

    Article Title: Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma

    doi: 10.1016/j.xcrm.2025.102077

    Figure Lengend Snippet: PTC209-induced DNA damage activates NF-κB signaling pathway in CSCs (A) Immunostaining and quantification of pH2A.X (red) in HNSCC cells treated with PTC209. DAPI stained the nuclei blue. Scale bar, 20 μm. (B) Percentage of pH2A.X in HNSCC cells from different treatment groups as indicated. Data are shown as the mean ± SD. ∗∗ p < 0.01 using an unpaired Student’s t test. (C) Western blot analysis of pH2A.X in HN6 and SCC15 cells treated with PTC209. (D and E) Histogram of the top 10 most-enriched GO (D) and KEGG (E) terms for upregulated genes (FC > 2) in ALDH + HN6 cells treated with PTC209. The red rectangles indicate genes related to NF-κB signaling. (F) Western blot analysis of pIKK-α/β, IKK-α, IKK-β, pIκB-α, IκB-α, p-P65, and P65 in HNSCC cells with PTC209 treatment. (G) Representative images of p65 immunostaining (green) in HN6 and SCC15 cells treated with PTC209. DAPI stained the nuclei (blue). Scale bar, 20 μm. See also .

    Article Snippet: The human HNSCC cell line SCC15 was from the American Type Culture Collection (ATCC, Manassas, VA, USA), and HN6 was from the Central Laboratory of Peking University School and the Hospital of Stomatology (Beijing, China).

    Techniques: Immunostaining, Staining, Western Blot

    IL-6 secreted from CSCs is responsible for non-stem tumor cells dedifferentiation (A) Heatmap of RNA-seq data for expression of genes encoding proinflammatory cytokines in ALDH + HN6 cells treated with PTC209. (B) Real-time qPCR analysis of IL-6 mRNA expression in HN6 and SCC15 cells treated with PTC209. Data are shown as the mean ± SD. ∗ p < 0.05 and ∗∗ p < 0.01 using an unpaired Student’s t test. (C) ELISA of protein levels of IL-6 secreted by HN6 and SCC15 cells treated with PTC209. Means ± SD are shown. ∗∗ p < 0.01 using an unpaired Student’s t test. (D) Real-time qPCR analysis of MYC in HN6 and SCC15 cells treated with IL-6. Data are shown as the mean ± SD. ∗∗ p < 0.01 using an unpaired Student’s t test. (E) Western blot analysis of MYC in HN6 and SCC15 cells treated with IL-6. (F) Experimental design used to label Bmi1 + CSCs after PTC209 plus IL-6 inhibitor treatment in mouse HNSCC tumors. (G) Representative images of mice with Bmi1 + Tomato + CSCs in HNSCC tumors from different treatment groups as indicated. The white dotted line indicates the boundary between tumor and interstitial tissues. Scale bar, 20 μm. (H) Percentage of Bmi1 + Tomato + CSCs in HNSCC tumors from different treatment groups as indicated. Data are shown as the mean ± SD. n = 5. ∗∗ p < 0.01 using one-way ANOVA. See also .

    Journal: Cell Reports Medicine

    Article Title: Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma

    doi: 10.1016/j.xcrm.2025.102077

    Figure Lengend Snippet: IL-6 secreted from CSCs is responsible for non-stem tumor cells dedifferentiation (A) Heatmap of RNA-seq data for expression of genes encoding proinflammatory cytokines in ALDH + HN6 cells treated with PTC209. (B) Real-time qPCR analysis of IL-6 mRNA expression in HN6 and SCC15 cells treated with PTC209. Data are shown as the mean ± SD. ∗ p < 0.05 and ∗∗ p < 0.01 using an unpaired Student’s t test. (C) ELISA of protein levels of IL-6 secreted by HN6 and SCC15 cells treated with PTC209. Means ± SD are shown. ∗∗ p < 0.01 using an unpaired Student’s t test. (D) Real-time qPCR analysis of MYC in HN6 and SCC15 cells treated with IL-6. Data are shown as the mean ± SD. ∗∗ p < 0.01 using an unpaired Student’s t test. (E) Western blot analysis of MYC in HN6 and SCC15 cells treated with IL-6. (F) Experimental design used to label Bmi1 + CSCs after PTC209 plus IL-6 inhibitor treatment in mouse HNSCC tumors. (G) Representative images of mice with Bmi1 + Tomato + CSCs in HNSCC tumors from different treatment groups as indicated. The white dotted line indicates the boundary between tumor and interstitial tissues. Scale bar, 20 μm. (H) Percentage of Bmi1 + Tomato + CSCs in HNSCC tumors from different treatment groups as indicated. Data are shown as the mean ± SD. n = 5. ∗∗ p < 0.01 using one-way ANOVA. See also .

    Article Snippet: The human HNSCC cell line SCC15 was from the American Type Culture Collection (ATCC, Manassas, VA, USA), and HN6 was from the Central Laboratory of Peking University School and the Hospital of Stomatology (Beijing, China).

    Techniques: RNA Sequencing, Expressing, Enzyme-linked Immunosorbent Assay, Western Blot